• Professor
  • Director, CBCB
  • Molecular, Cellular, and Developmental Biology
  • Ph.D.
  • Department of Biology
  • Temple University

We use a combination of computer simulations, statistical mechanics, and modeling to study the structure, function, folding, and dynamics of proteins in solution. We are interested in the interplay between computational models and experiments at different levels of spatial and temporal resolution from atomic to mesoscopic, and from femtoseconds to seconds or longer.

Our current research activities include:

  • New multi-scale models, effective potentials, and sampling methods for molecular simulations
  • Protein folding and misfolding: fundamental physics, health-related applications
  • Ligand binding to protein receptors and drug design
  • Protein evolution, stability, and drug resistance: bioinformatics and biophysics